7 Signs Your Skin's NAD+ is Depleting
(And What You Can Do About It, According to Harvard Scientists)
Most signs of aging that you see on your skin are actually the result of declining NAD+. It's the molecule that powers every skin cell in your body. Aramore was developed to restore it.
It's not your skincare routine. The real answer might surprise you.
You moisturize. You tone. You've tried the serums everyone recommends. Something still feels off.
Your skin isn't responding the way it used to. The glow is gone. The firmness is fading.
It's not that you're doing something wrong. Most skincare was never designed to address what's happening to your skin at the biological level. Here are 7 signs that your skin's NAD+ levels are declining — and why that changes everything about your skin.
Sign no.1
Your skin looks dull no matter what products you use
You layer on the serums and moisturizers. There's a glow for a few hours. Then it fades.
That's not a hydration problem. It's a cell energy problem.
Skin radiance comes from healthy new skin cells cycling up to the surface of skin from the basal layer. When NAD+ levels decline, stem cells become underpowered and produce fewer and less resilient skin cells. The dullness you're seeing is the result of a lack of cellular energy.
Sign no.2
Fine lines and wrinkles keep appearing
You've got a skincare routine and you're mindful about your health, but fine lines are persistent.
Here's what most people don't know. The structural integrity of your skin that keeps it smooth and firm depends on the energy your skin cells generate. That energy comes from NAD+. As NAD+ levels decline starting in your 20s, the integrity of your skin barrier and cellular layers becomes compromised, and that's when lines and wrinkles start to form.
Those lines aren't just a surface issue. They're a sign your skin's foundational energy supply is running low.
Sign no.3
Your skin texture never feels smooth, no matter how much you exfoliate
Smooth skin texture depends on your skin's ability to renew itself efficiently. Every 28 days, healthy skin cycles through a complete cellular regeneration. Old cells shed, new cells rise. This process is powered by NAD+.
When NAD+ levels drop, that cycle slows down. Old cells linger. New cells are sluggish. No exfoliant can repair regeneration problems happening at the cellular level.
Sign no.4
Your skin has lost firmness
You remember when your skin bounced back. Now it doesn't. You may even notice skin starting to sag, especially in areas like the lower face.
Firmness is structural. It's determined primarily by how well your skin cells are functioning at a deep level. Energized skin stem cells continuously produce new, healthy skin cells that maintain the epidermis's integrity.
When NAD+ levels fall, our skin produces fewer new cells and our skin density lessens, thinning the epidermis. Traditional topical skincare only reaches the surface layer of cells and can't rebuild what was lost at the source.
Sign no.5
Dark spots and hyperpigmentation won't budge, no matter what you try
Vitamin C. Acids. Hydroquinone. You've spent real money trying to fade spots that never seem to lighten, even though you're using all the recommended skincare ingredients.
Persistent hyperpigmentation is often a sign of sluggish skin cell turnover. Not just sun damage. When cells aren't renewing at a healthy rate, the processes that normally fade discoloration stall out.
In Aramore's 8-week clinical trial, 100% of participants saw measurable improvement in dark spots and evenness of tone. The difference? Targeting the root cause — cell energy driving consistent, even renewal, not the spot itself.
Sign no.6
Your skin feels more fragile and more reactive than it used to
Things that never bothered your skin now cause redness. Breakouts that healed in three days now take two weeks. Your skin feels more prone to irritation.
A thinner, more reactive epidermis is a direct consequence of a compromised barrier. When NAD+ declines, stem cells produce fewer new skin cells. Your skin barrier weakens.
In clinical testing, Aramore's formula produced a 53% increase in skin barrier strength in 8 weeks. Not because it coats the surface, but because it restores the cellular energy that builds the barrier from within.
Sign no.7
You've accepted these changes as part of normal aging, but still wish your skin felt healthier
Aging is, of course, natural. But the visible signs of skin aging that most of us experience aren't just inevitable biology. They're the downstream effect of a single molecule declining faster than necessary. NAD+ levels drop by around 50% by the time you're in your 50s. That decline is the root cause of most of the changes you see in the mirror.
And for the first time, there's something that addresses it. Not by masking the signs, but by restoring the cellular processes that keep skin healthy, protected, and strong.
If you recognized even a few of those signs, here's what you need to know
It's not your routine. It's not your genetics. And it's not something you can fix with traditional skincare.
Your skin (and really, your whole body) runs on cellular energy. That energy is generated by a molecule called NAD+. NAD+ starts to naturally decline in your 20's, and declines by up to 50% by the time you reach your 50s. When it drops, your skin's stem cells become underpowered. They produce fewer new skin cells, the renewal process becomes less efficient, and your skin barrier thins. The signs you've likely been trying to address (dullness, lines, uneven tone, lost firmness) aren't separate problems. They're the same problem, showing up in different ways.
Most skincare works on the surface. It can hydrate, smooth, and temporarily brighten. But it can't change what's happening at the cellular level.
Our co-founder, Dr. Anna Mandinova of the Harvard Stem Cell Institute, discovered how to change that.
Introducing the NAD+ Cell Energizing Treatment
The first clinically-proven topical treatment to boost NAD+ in skin cells. Developed by Harvard and MIT scientists through 7 years of research.
How it works
NAD+ itself is too large to penetrate skin, so it can't be delivered directly in a topical product.
Dr. Mandinova's research showed that the right combination of NMN (an NAD+ precursor), ketone bodies, and fatty acids signals NAD+ production directly inside the epidermis. This had never been done before.
The result is a treatment that doesn't sit on the surface of skin, but instead works deep beneath it.
What the clinical trial showed
We ran an independent 8-week clinical trial with 29 women aged 44 to 61.
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What people are saying
"I have done clinical trials for most major cosmetic companies and I have never seen results like these."
"I can barely see my fine lines now. I have crossed into my forties and knew I needed to get serious. But I was struggling to find a regimen that didn't have fifty steps and actually worked. NAD+ really is as amazing as everyone says."
"I went to the med spa where I get my Botox and from the moment I walked in, every person there was raving about my skin. One provider suggested it was from a BBL or Halo treatment. I haven't had a laser treatment in almost 6 years. It is this product."
"Aramore was the holy grail I never expected to find. I have spent more money than I will publicly admit trying to address my hyperpigmentation, oily skin, and texture. Aramore has given me normal skin for the first time in my life."
"I am a skincare girl. I try it all. I will not be trying anything else. This is my forever brand. My skin has never looked or felt better."
"I have noticed an incredible improvement in the fine lines under my eyes and on my forehead. They are significantly less apparent. I've experienced firmer and more resilient-looking skin overall."
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Your questions, answered
NAD+ (Nicotinamide Adenine Dinucleotide) is a molecule found inside the mitochondria of every living cell, including your skin cells. It's the coenzyme responsible for generating the cellular energy your skin needs to function. Without it, stem cells can't produce new, healthy skin cells. NAD+ starts declining in your 20s and can be up to 50% lower by your 50s. That decline is the root cause of most visible aging.
You're right that NAD+ itself is too large a molecule to penetrate the skin barrier. That's exactly the problem our co-founder Dr. Anna Mandinova set out to solve. Her research showed that a specific combination of NMN (an NAD+ precursor), ketone bodies, and fatty acids — formulated correctly — can penetrate the epidermis and signal NAD+ production inside the skin cell. We don't deliver NAD+ directly. We deliver the building blocks your skin uses to make more of it.
Yes, fundamentally. Vitamin C, acids, and most anti-aging ingredients work on the surface of the skin. They can temporarily smooth texture, brighten, or hydrate through surface-level mechanisms. Aramore works at the level of the skin cell itself, by restoring the cellular energy that drives all of those processes naturally. Many users incorporate Aramore into their existing routine and find their other products work better as a result.
Aramore is engineered to work with your skin's natural 28-day regenerative cycle. Most notice a change in skin quality — improved texture, hydration, and radiance — by the end of those 28 days. The full spectrum of benefits, including firming, more evenness of tone, and hyperpigmentation reduction, typically becomes more visible over 8 weeks of consistent daily use. Just like with building muscle, results compound over time as your skin gets healthier and stronger. The longer your cells operate with restored NAD+ levels, the more improvement you'll see.
Yes. Aramore is fragrance-free, hypoallergenic, and dermatologist-tested. No parabens, SLS, SLES, DEA, essential oils, heavy metals, talc, or mineral oil. Vegan and cruelty-free. In clinical testing, the formula performed well across skin types, including sensitive skin. If you have a specific skin condition or are pregnant, consult your dermatologist as you would with any new skincare.
Most products that use the word NAD+ on the label contain a basic niacinamide compound with no meaningful penetration mechanism or clinical backing. Aramore's formulation was developed over 7 years by PhD scientists from Harvard and MIT. It is the only topical NAD+ treatment backed by an independent human clinical trial showing 100% improvement across all measured outcomes. The delivery system that allows NAD+ precursors to reach the epidermis cannot be replicated at a low price point.
If you're not satisfied within 30 days of receiving your order, we'll refund you in full. No questions asked. We offer this because we've seen what happens when skin cells are given back their energy.
It's time to restore what your skin has lost
NAD+ depletion is real. And now, for the first time, it's addressable. Not with another surface treatment, but with a science-backed, clinically-proven formula that goes where nothing else has gone before — directly to your skin cells, where aging actually starts.
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Developed by Harvard and MIT Scientists
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100% of Clinical Trial Participants Saw Improvement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results based on an 8-week independent clinical trial of 29 female participants aged 44 to 61.